POSSIBLE ROLE OF IL-1-? AND TNF-? IN BREAST CANCER

Abstract

Background: Cytokines have been used as biomarkers in research for prognosis and have been associated with symptoms and adverse outcomes in multiple conditions, including breast cancer.
Objectives: To estimate the concentration of IL-1-? and TNF-? in serum of breast cancer (BC) patients compared with control groups and to detect if there is association of serum levels of these interleukins with disease development.
Subjects and Methods: The levels of IL-1-? and TNF-? were measured by ELISA method in sera of 45 BC patients, 12 patients with benign breast lesions and 23 apparently healthy controls.
Results: Present study was demonstrated that IL-1-? and TNF-? levels were significantly elevated in serum of BC patients as compared with controls (p<0.001), this elevation were significantly associated with poor prognostic factors including advanced stage and estrogen and progesterone receptors-negative status.
Conclusions: Evaluation the serum level of IL--?1and TNF-? may be helpful as predictive non-invasive tests for tumor development in breast cancer patients.
Keywords: Breast cancer, IL--?1, TNF-?.