THE EFFECTIVENESS OF SYSTEMIC CO-ENZYME Q10 IN VITILIGO

Abstract

Background: Vitiligo is the most frequent depigmentation disorder of the skin. None of the therapeutic alternatives is satisfactory.
Objective:To evaluate the effectiveness of systemic Co-enzyme Q10 in patients with vitiligo.
Methods:Twelve patients received Co-enzyme Q10 75 mg twice daily compared with 12 patients received placebo capsule twice daily orally for 8 weeks in the Department of Dermatology, Al-Kadhimiya Teaching Hospital (November 2011 to march 2012). History of patients was taken and measurement for serum glutathione (S. GSH) (by Elleman methods), malonialdehyde (S. MDA) (by Stocks and Dormandy methods) and VASI score at baseline, 4 and 8 weeks interval.
Results:No significant difference in S. GSH was found between Co-enzyme and placebo group after 4 and 8 weeks. High significant decrease in S. MDA occurred after 4 and 8 weeks with significant decrease in VASI were found after 8 weeks.
Conclusion:Co-enzyme Q10 may have a role in treatment of vitiligo.
Keywords:Co-enzyme Q 10, Vitiligo, Antioxidant.