Antiangiogenic Activity of 4-Chloro Phenyl Carbothioamide Indole Derivative Using the In Vivo Chorioallantois Membrane Assay

Abstract

Background:    New blood vessels are formed by two basic processes; namely ‎vasculogenesis and angiogenesis. Vasculogenesis is the de ‎novo formation of initial vascular networks. Once the vascular networks are ‎formed, new blood vessels are formed by sprouting or splitting from ‎pre-existing vessels in an angiogenesis process.
Objective:    To investigate the anti-angiogenic activity of 2-(5-bromo - 1H- indole -2- carbonyl) -N- (4-chlorophenyl) hydrazine -1- carbothioamide indole derivative. 
Methods: The antiangiogenic activity of the test Indoles derivative was ‎evaluated using the in-vivo chorioallantois membrane assay
Results: The tested compound significantly (P <0.05) distorted and suppressed the growth of blood vessels in the chorioallantois membrane assay
Conclusion: This study showed that (4-chloro phenyl carbothioamide indole derivative) significantly inhibits the ‎angiogenesis process and could be a potentially promising angiogenesis ‎inhibitor lead compound. 
Keywords: Anti-angiogenesis, vasculogenesis, ‎chorioallantois membrane assay, 4-chloro phenyl carbothioamide indole derivative
Citation: Ali ZM. , Kadhim HM. Antiangiogenic activity of 4-Chloro phenyl carbothioamide indole derivative using the in vivo chorioallantois membrane assay. Iraqi JMS. 2025; 23(1): 171-176. doi: 10.22578/IJMS.23.1.20